Biggest NFL Week 10 Point Spreads and Betting Lines

The NFL Week 10 point spreads highlight multiple lopsided clashes and high-scoring projections across a 14-game slate. According to lines provided at bet365 Sportsbook as of November 8, three teams enter the week favored by seven points or more. The schedule begins with a Thursday game between Washington and the New York Giants, while the Chicago Bears, Denver Broncos, Philadelphia Eagles, and Tampa Bay Buccaneers have byes.

Largest Point Spreads on the Board

The Jacksonville Jaguars hold the largest advantage on the board. Jacksonville sits as a -9.5 favorite against the Tennessee Titans, carrying a -500 moneyline compared to Tennessee's +380. The over/under for the matchup is set at 46.5.

The Buffalo Bills follow closely, favored by -8.5 points over the New York Jets. Buffalo holds a -550 moneyline while the Jets sit at +410, with the total set at 51.5. The Los Angeles Rams round out the biggest favorites, laying -7 points against the Arizona Cardinals. The Rams carry a -310 moneyline against the Cardinals' +250, with an over/under of 45.5.

High Totals and Moderate Margins

Oddsmakers project plenty of offense when the San Francisco 49ers meet the Dallas Cowboys. The matchup boasts a slate-high 55.5 over/under, with the 49ers favored by -4.5 points and holding a -225 moneyline over the Cowboys (+185). The Detroit Lions and New England Patriots also feature a high 50.5 total. Detroit enters as a -2.5 favorite with a -142 moneyline against New England (+120).

Conversely, two matchups feature totals under 40 points. The Baltimore Ravens and Los Angeles Chargers face a 38.5 over/under, with Baltimore favored by -4.5 (-185 moneyline) against the Chargers (+154). The Houston Texans and Cleveland Browns sit at a 39.5 total, where Houston is a -4.5 favorite (-192 moneyline) against Cleveland (+160).

Field Goal and Narrow Lines

The Week 10 schedule features several games with a spread of exactly three points. The Kansas City Chiefs are -3 favorites (-175 moneyline) over the Atlanta Falcons (+145), with an over/under of 46.5. The Green Bay Packers are also favored by -3 points (-170 moneyline) against the Minnesota Vikings (+142), carrying a 42.5 total. The Seattle Seahawks match that margin, sitting as -3 favorites (-166 moneyline) over the Las Vegas Raiders (+140), with the total set at 42.5.

The Cincinnati Bengals are favored by slightly more, laying -3.5 points (-170 moneyline) against the Pittsburgh Steelers (+142), with a 47.5 over/under.

The narrowest spreads of the week sit at just 1.5 points. The Thursday night opener sees the New York Giants as -1.5 favorites over the Washington Commanders. New York holds a -125 moneyline against Washington's +105, with the total set at 43.5. The Carolina Panthers are also slight -1.5 favorites (-120 moneyline) against the New Orleans Saints (+100), with a 47.5 over/under. Finally, the Indianapolis Colts are -2.5 favorites (-135 moneyline) over the Miami Dolphins (+114), carrying a 41.5 total.