Offense
25| Player | No. | Pos | Age | Ht | Wt | College | Exp |
|---|---|---|---|---|---|---|---|
 Jake Brendel |
64 | C | 34 | 6' 4" | 299 lbs | UCLA | 9 |
 Kyle Juszczyk |
44 | FB | 35 | 6' 2" | 235 lbs | Harvard | 14 |
 Connor Colby |
75 | G | 23 | 6' 5" | 309 lbs | Iowa | 2 |
 Colton McKivitz |
68 | OT | 30 | 6' 6" | 301 lbs | West Virginia | 7 |
 Trent Williams |
71 | OT | 38 | 6' 5" | 320 lbs | Oklahoma | 17 |
 Adrian Martinez |
4 | QB | 26 | 6' 2" | 220 lbs | Kansas State | 2 |
 Mac Jones |
10 | QB | 28 | 6' 3" | 220 lbs | Alabama | 6 |
 Brock Purdy |
13 | QB | 26 | 6' 1" | 220 lbs | Iowa State | 5 |
 Kurtis Rourke |
14 | QB | 26 | 6' 4" | 220 lbs | Indiana | 1 |
 Christian McCaffrey |
23 | RB | 30 | 5' 11" | 210 lbs | Stanford | 10 |
 Kaelon Black |
26 | RB | 25 | 5' 9" | 208 lbs | Indiana | – |
 Jordan James |
29 | RB | 22 | 5' 9" | 208 lbs | Oregon | 2 |
 Khalil Herbert |
40 | RB | 28 | 5' 9" | 212 lbs | Virginia Tech | 6 |
 Brayden Willis |
9 | TE | 26 | 6' 4" | 240 lbs | Oklahoma | 4 |
 Hayden Rucci |
40 | TE | 25 | 6' 5" | 247 lbs | Wisconsin | 1 |
 George Kittle |
85 | TE | 33 | 6' 4" | 250 lbs | Iowa | 10 |
 Luke Farrell |
89 | TE | 29 | 6' 5" | 250 lbs | Ohio State | 6 |
 Jacob Cowing |
4 | WR | 25 | 5' 9" | 171 lbs | Arizona | 3 |
 Mike Evans |
5 | WR | 33 | 6' 5" | 231 lbs | Texas A&M | 13 |
 Jordan Watkins |
17 | WR | 24 | 5' 11" | 196 lbs | Ole Miss | 2 |
 Deebo Samuel |
19 | WR | 30 | 6' 0" | 215 lbs | South Carolina | 8 |
 Malik Turner |
81 | WR | 30 | 6' 2" | 202 lbs | Illinois | 5 |
 Trenton Irwin |
82 | WR | 30 | 6' 2" | 204 lbs | Stanford | 6 |
 Brandin Cooks |
84 | WR | 33 | 5' 10" | 189 lbs | Oregon State | 13 |
 KhaDarel Hodge |
86 | WR | 31 | 6' 2" | 210 lbs | Prairie View A&M | 9 |
Defense
36| Player | No. | Pos | Age | Ht | Wt | College | Exp |
|---|---|---|---|---|---|---|---|
 Renardo Green |
0 | CB | 25 | 6' 0" | 186 lbs | Florida State | 3 |
 Deommodore Lenoir |
2 | CB | 27 | 5' 10" | 200 lbs | Oregon | 6 |
 Upton Stout |
20 | CB | 24 | 5' 9" | 181 lbs | Western Kentucky | 2 |
 Jack Jones |
25 | CB | 28 | 5' 11" | 175 lbs | Arizona State | 5 |
 Darrell Luter Jr. |
25 | CB | 26 | 6' 0" | 190 lbs | South Alabama | 4 |
 Ephesians Prysock |
28 | CB | 23 | 6' 3" | 196 lbs | Washington | – |
 Eli Apple |
30 | CB | 31 | 6' 1" | 203 lbs | Ohio State | 10 |
 Matthew Judon |
36 | DE | 34 | 6' 3" | 275 lbs | Grand Valley State | 10 |
 Khalid Kareem |
47 | DE | 28 | 6' 4" | 268 lbs | Notre Dame | 4 |
 Keion White |
56 | DE | 27 | 6' 5" | 290 lbs | Georgia Tech | 4 |
 Jah Joyner |
59 | DE | 24 | 6' 4" | 262 lbs | Minnesota | – |
 Romello Height |
94 | DE | 25 | 6' 2" | 239 lbs | Texas Tech | – |
 Nick Bosa |
97 | DE | 29 | 6' 4" | 266 lbs | Ohio State | 8 |
 Mykel Williams |
98 | DE | 22 | 6' 5" | 267 lbs | Georgia | 2 |
 Sebastian Valdez |
55 | DT | 24 | 6' 3" | 301 lbs | Washington | 1 |
 Kevin Givens |
90 | DT | 29 | 6' 1" | 285 lbs | Penn State | 7 |
 Osa Odighizuwa |
92 | DT | 28 | 6' 2" | 294 lbs | UCLA | 6 |
 Gracen Halton |
93 | DT | 22 | 6' 2" | 293 lbs | Oklahoma | – |
 Bryson Eason |
94 | DT | 24 | 6' 3" | 315 lbs | Tennessee | – |
 James Thompson Jr. |
96 | DT | 24 | 6' 6" | 308 lbs | Illinois | – |
 Deion Jones |
0 | LB | 31 | 6' 1" | 222 lbs | LSU | 10 |
 Jalen Graham |
41 | LB | 25 | 6' 3" | 220 lbs | Purdue | 3 |
 Larry Worth |
47 | LB | 21 | 6' 4" | 226 lbs | Arkansas | – |
 Tatum Bethune |
48 | LB | 25 | 6' 1" | 230 lbs | Florida State | 3 |
 Garret Wallow |
49 | LB | 27 | 6' 2" | 230 lbs | TCU | 6 |
 Luke Gifford |
51 | LB | 31 | 6' 3" | 243 lbs | Nebraska | 8 |
 Jaden Dugger |
53 | LB | 22 | 6' 4" | 240 lbs | Louisiana | – |
 Fred Warner |
54 | LB | 29 | 6' 3" | 230 lbs | BYU | 9 |
 Dre Greenlaw |
57 | LB | 29 | 6' 0" | 230 lbs | Arkansas | 8 |
 Ogbonnia Okoronkwo |
59 | LB | 31 | 6' 2" | 253 lbs | Oklahoma | 9 |
 Malik Mustapha |
6 | S | 24 | 5' 10" | 206 lbs | Wake Forest | 3 |
 Ashtyn Davis |
24 | S | 30 | 6' 1" | 205 lbs | California | 7 |
 Patrick McMorris |
24 | S | 24 | 6' 0" | 206 lbs | California | 3 |
 Ji'Ayir Brown |
27 | S | 26 | 5' 11" | 202 lbs | Penn State | 4 |
 Siran Neal |
33 | S | 32 | 6' 0" | 206 lbs | Jacksonville State | 9 |
 Marques Sigle |
36 | S | 24 | 5' 11" | 199 lbs | Kansas State | 2 |
Special teams
2| Player | No. | Pos | Age | Ht | Wt | College | Exp |
|---|---|---|---|---|---|---|---|
 Corliss Waitman |
15 | P | 31 | 6' 2" | 210 lbs | South Alabama | 4 |
 Eddy Pineiro |
18 | PK | 31 | 5' 11" | 190 lbs | Florida | 9 |
Players
12| Player | No. | Pos | Age | Ht | Wt | College | Exp |
|---|---|---|---|---|---|---|---|
 Drake Nugent |
66 | C | 25 | 6' 1" | 300 lbs | Michigan | 1 |
 Jakob Robinson |
0 | CB | 26 | 5' 10" | 181 lbs | BYU | 2 |
 Quinton Bell |
0 | DE | 30 | 6' 4" | 258 lbs | Prairie View A&M | 5 |
 Titus Leo |
0 | DE | 26 | 6' 3" | 245 lbs | Wagner | 3 |
 Viliami Fehoko |
61 | DE | 26 | 6' 4" | 267 lbs | San José State | 2 |
 Naquan Jones |
50 | DT | 28 | 6' 3" | 313 lbs | Michigan State | 7 |
 Zamir White |
33 | RB | 27 | 6' 0" | 227 lbs | Georgia | 5 |
 Sincere McCormick |
35 | RB | 26 | 5' 8" | 204 lbs | UTSA | 3 |
 Jalen Stroman |
38 | S | 23 | 6' 1" | 203 lbs | Notre Dame | – |
 Josiah Deguara |
0 | TE | 29 | 6' 2" | 238 lbs | Cincinnati | 6 |
 Wesley Grimes |
18 | WR | 22 | 6' 2" | 194 lbs | NC State | – |
 Will Pauling |
84 | WR | 23 | 5' 9" | 183 lbs | Notre Dame | – |
Players
9| Player | No. | Pos | Age | Ht | Wt | College | Exp |
|---|---|---|---|---|---|---|---|
 Victor Dimukeje |
96 | DE | 26 | 6' 2" | 250 lbs | Duke | 6 |
 Sam Okuayinonu |
91 | DT | 28 | 6' 1" | 269 lbs | Maryland | 4 |
 Alfred Collins |
95 | DT | 25 | 6' 5" | 332 lbs | Texas | 2 |
 CJ West |
99 | DT | 24 | 6' 1" | 316 lbs | Indiana | 2 |
 Nickolas Martin |
45 | LB | 24 | 5' 11" | 221 lbs | Oklahoma State | 2 |
 Xavier Thomas |
50 | LB | 26 | 6' 2" | 250 lbs | Clemson | 2 |
 Patrick Taylor |
32 | RB | 28 | 6' 2" | 217 lbs | Memphis | 6 |
 De'Zhaun Stribling |
7 | WR | 23 | 6' 2" | 207 lbs | Ole Miss | – |
 Demarcus Robinson |
11 | WR | 32 | 6' 1" | 202 lbs | Florida | 11 |
Injury report
| Player | Status | Details | Date |
|---|---|---|---|
| Garret Wallow |
Questionable | Hamstring - Questionable for Week 9 vs. Las Vegas | Oct 26 |
| Nick Bosa |
Questionable | Knee - Questionable for Week 9 vs. Las Vegas | Oct 26 |
| Luke Gifford |
Questionable | Groin - Questionable for Week 9 vs. Las Vegas | Oct 26 |
| Upton Stout |
Questionable | Shoulder - AC Joint - Questionable for Week 9 vs. Las Vegas | Oct 26 |
| Christian McCaffrey |
Questionable | Hamstring - Questionable for Week 9 vs. Las Vegas | Oct 26 |
| Mike Evans |
Questionable | Achilles - Questionable for Week 9 vs. Las Vegas | Oct 26 |
| Marques Sigle |
Questionable | Ankle - Questionable for Week 9 vs. Las Vegas | Oct 26 |
 Nate Hobbs |
I.L. | I.L. - Groin | Oct 22 |
| Nickolas Martin |
I.L. | I.L. - Hamstring | Oct 22 |
 Austen Pleasants |
I.L. | I.L. - Knee | Oct 22 |
 Isaac Guerendo |
PUP | Pectoral - Physically Unable to Perform. Expected Return - Week 9 | Oct 22 |
| Demarcus Robinson |
I.L. | I.L. - Ankle | Oct 15 |
| KhaDarel Hodge |
Questionable | Knee - Questionable for Week 5 at Seattle | Oct 7 |
 Nick Zakelj |
I.L. | I.L. - Undisclosed | Oct 2 |
 Jake Tonges |
I.L. | I.L. - Knee - MCL | Oct 2 |
 Darrick Forrest |
I.L. | I.L. - Undisclosed | Oct 2 |
 Mikail Kamara |
I.L. | I.L. - Knee | Oct 2 |
| Alfred Collins |
I.L. | I.L. - Knee | Oct 2 |
| Sam Okuayinonu |
I.L. | I.L. - Foot | Oct 2 |
 Ricky Pearsall |
I.L. | I.L. - Knee - PCL | Sep 28 |